[cnn-photo-caption image=http://i2.cdn.turner.com/cnn/2009/POLITICS/07/15/clinton.speech/art.clintonspeech.gi.jpg caption="Secretary of State Hillary Clinton delivers a foreign policy address Wednesday."]
Iran's crackdown on protests after its disputed presidential election has "shifted" its prospects for direct talks with the United States, but they remain on the table, Secretary of State Hillary Clinton said Wednesday.
The Obama administration has held open its offer of talks with Iran - which has not had diplomatic relations with Washington since 1980 - despite the clampdown on protesters in Tehran and other cities.
Clinton said that offer remains the "best vehicle" for engaging Tehran - but as President Obama said last week, she said it "will not remain indefinitely."
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